Upcoming | Revealing the Road to Advancing the New Second Generation Endocrine Factor Proteins of DIA-UP, See How to Accelerate the Development of VB12 Reagents!

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Intrinsic factorIt is a glycoprotein secreted by the parietal cells of Gastric mucosa. IF combines with Vitamin B12 to form a complex. Vitamin B12 participates in energy metabolism in the body through a series of important Enzyme catalysis, including the conversion of homocysteine to methionine, Methylmalonic acid to Succinyl-CoA, and methyl tetrahydrofolate to tetrahydrofolate, which is necessary for DNA synthesis and hematopoiesis.The absorption of Vitamin B12 needs the help of internal factor (IF), which is mainly applied to the determination of serum Vitamin B12.


New second-generation endogenous factor protein accelerates the development of VB12 reagent

DIA-UP As a leading global in vitro diagnostic upstream platform enterprise, we have been deeply involved in the core biological raw materials of reagents for over a decade and are a professional provider of special proteins and small molecule raw materials. The raw materials have been repeatedly tested and verified on multiple platforms, and a more systematic and rigorous process and management system has been adopted for effective quality control. The first generation of endogenous factor protein independently developed by De Aoping has received widespread praise. Through continuous exploration and iterative optimization by the core technology team, the advanced version of endogenous factor protein II has been innovatively launched. After multi-step column chromatography, the new generation of internal factor protein can bind VB12>0.95mol in 1mol, which has higher sensitivity, higher binding ability and better reagent performance. At the same time, De Aoping has established a more secure and stable supply chain, with stable delivery times and fast response, which can maximize the reduction of customer time costs and efficiently promote the stable development of experimental work.




Advanced Advantages

✓ Higher sensitivity

✓ Higher combination capability

✓ Better reagent performance

Character: Clear and transparent

Source: Mammalian cells

Buffer system: water

Purity: greater than 95% by HPLC

Concentration: see the label on the test tube

Filtration: 0.22um

Scope of application: This product is suitable for the development of VB12 related reagents

Storage conditions: For long-term storage, please freeze below -20 ° C. Avoid repeated freeze-thaw cycles

Attention: The optimal working concentration may vary under different experimental conditions. Please determine the optimal working concentration based on the pre test results

Intrinsic factor protein II


Performance Demonstration

The new generation of intrinsic factor proteins undergo multi-step column chromatography, and 1mol of intrinsic factor can bind VB12 with a concentration of>0.95mol:


The above results are for testing pure VB12, and the blood sample VB12 dissociation plan is about to be launched


Limited Time Experience

30 free trial packs for a limited time, experience immediately!

Apply on 'Code'

Deadline for free application: August 15, 2023

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For inquiries about IVD raw materials and research services related products, please contact us through the following methods——


Tel : 185 1363 7192 / 186 1089 6066

E-mile : order@dia-up.com

Add : Building 18, Yard 2, Huanke Middle Road, Tongzhou District, Beijing




DIA-UP was established in 2012, with a professional technical research and development team with over 10 years of experience, and has won multiple invention patents. The company has built a research and development platform for in vitro diagnostic materials (covering 10 major product systems, including primer and probe synthesis, nucleic acid molecular detection materials, immune reagent materials, biochemical reagent materials, hemagglutination reagent materials, fluorescent immunochromatography POCT large plate, biochemical reagent large package, hemagglutination reagent large package, calibration quality control products, etc.), automated high-throughput DNA reading and writing platform, RNA Intelligent design and synthesis platform, protein antibody preparation platform Five core technology platforms, including the supply platform for scientific research reagents and consumables.

DIA-UP adopts a 100000/10000 level purification workshop for product production and packaging, strictly adhering to the ISO13485:2016 quality management system standards, adhering to the development concept of 'craftsmanship quality, customer achievement', and committed to providing high-quality products and services to customers in the field of in vitro diagnosis and scientific research.

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