Three Reactive Groups Available
01. Amino Reactive Group——NHS/PNP/PFP/COOH
1.1 NHS
1.2 PFP
1.3 PNP
1.4 Isothiocyanate
Typical substances such as FITC (fluorescein isothiocyanate), which shows highly efficient amino-reactive property.
02. Click Reactive Group——Azide/DBCO/Alkyne/Tetrazine/TCO/BCN
Two types: copper-free catalysis and copper-catalyzed:
1）copper-free catalysis：DBCO+Azide、TCO+Azide,、BCN+Azide
2）copper-catalyzed：Azide+Alkyne，After conjugation, monovalent copper ions can be eliminated to avoid the influence of cytotoxicity.
03. Thiol Reactive Group——Maleimide/SPDP/ PyS₂
Including:
Reaction between SH groups (Disulfide bond formation)
Reaction between SH and Maleimide (Michael addition reaction)
Reaction between SH and sulfonic acid group (Thiol-sulfonic acid reaction)
Customer Case | Mass Spectrometry Detection Report
✓ Mass - Molecular Weight 18572.7
✓ Base Sequence- PROTAC_0876_vhl032：(VHL032)(DBCO)AG oligo***CT (Quasar570)
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