Inflammation is a defense response of living tissues with vascular systems to injury, and is a common clinical condition. Pathogenic diagnosis is of great significance for the treatment of infections, but the detection of pathogenic microorganisms takes a long time and has a low positive rate, which limits its value in the early diagnosis and treatment of infections. In recent years, the elevation of some biomarkers in the peripheral circulation can change in the early stages of infection, providing a basis for early treatment of infection.